![]() Data are based on moderate quality evidence. When added to antipsychotic drugs valproate probably increases the chance of improvement. Valproate was associated with a number of adverse events among which sedation and dizziness appeared more frequently than in the control groups. Schizophrenia Ī 2016 systematic review compared the efficacy of valproate as an add-on for people with schizophrenia: There is limited evidence that adding valproate to antipsychotics may be effective for overall response and also for specific symptoms, especially in terms of excitement and aggression. Valproate products are also used to treat manic or mixed episodes of bipolar disorder. It has also been successfully given intravenously to treat status epilepticus. ![]() Valproate has a broad spectrum of anticonvulsant activity, although it is primarily used as a first-line treatment for tonic–clonic seizures, absence seizures and myoclonic seizures and as a second-line treatment for partial seizures and infantile spasms. It is also used to prevent migraine headaches. It is used primarily to treat epilepsy and bipolar disorder. The sodium salt of the acid is sodium valproate and a coordination complex of the two is known as valproate semisodium. Valproic acid (VPA) is an organic weak acid.
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